Enigmatic Club & other: August 2008

Sunday 24 August 2008

Synthetic Moleculues Could Add Spice To Fight Against Cancer

�Turning up the heat on the red love apple during processing has the potential to give the popular garden staple added disease-fighting mogul, Ohio State University research suggests.

Scientists birth found that lycopene molecules in tomatoes that ar combined with fat and subjected to intense heat during processing are restructured in a way that appears to ease their transport into the blood stream and tissue. The tomato is the primary food source of lycopene, a naturally occurring pigment joined to the prevention of cancer and other inveterate diseases.

In its standard structure in the average red tomato, the lycopene atom is set out in a linear configuration. That structure seems to hinder the molecule's absorption through intestinal walls and into the roue, said Steven Schwartz, an investigator in Ohio State's Comprehensive Cancer Center and a professor of intellectual nourishment science and technology at Ohio State.

Meanwhile, most of the lycopene that is found circulating in human blood is configured in a bent molecular form. This means that either the human body somehow transforms lycopene molecules through reactions that have so far to be identified, or that the bent molecular structures of lycopene are much more than likely to be engrossed into the blood and transported to tissue - a necessary step in preventing disease.

Assuming the latter is genuine, Schwartz and colleagues take in devised a way to process red tomatoes - the form preferred by American consumers - into a sauce that contains bent molecular forms of lycopene. A clinical tryout conducted in collaboration with Steven Clinton, a medical oncologist and physician scientist in Ohio State's Comprehensive Cancer Center, showed that people had more lycopene in their blood after eating the specially processed sauce than they did after eating regular red River tomato sauce.

Schwartz described the research at the American Chemical Society meeting in Philadelphia.

In the food skill world, processing gets a bad tap for its tendency to deplete vegetables of nutrients, change their color and often negatively affect how they taste.

"Instead, here is a sheath where processing is positive in terms of enhancing absorption of lycopene," aforementioned Schwartz.

Lycopene belongs to a family of antioxidants called carotenoids, which give certain fruits and vegetables their distinctive colors. Carotenoids' antioxidant properties are associated with protecting cells and regulating cell ontogeny and death, all of which play a role in multiple disease processes.

In its natural state, lycopene in a red tomato is in what is called an all-trans constellation, characterized by its running form. The molecular structure of lycopene circulating in human rakehell is in what is called a cis-isomer configuration, or a bent form. The chemical properties ar the same - only the form differs.

"What we have ground is we can take the red tomato molecular form of lycopene and by processing it and heating it in combination with added oil, we can change the embodiment of the molecule so it is configured in this knack form," Schwartz said.

Heat is essential to the sue, but so is adding some productive, Schwartz said. In late work, he and colleagues determined that consuming fat and carotenoids simultaneously improved absorption of lycopene and other compounds, but the scientists weren't sure incisively why.

When humans eat fats, or lipids, the body produces midget droplets of fat called lipid micelles during digestion that ar easily taken up through the intestinal wall and absorbed into the bloodstream.

Continuing research has led Schwartz to speculate that lycopene in its linear form tends to stack and become crystalised, which lowers, but does not reject, its absorption potential. But the knack forms of lycopene are able to more easily find their way into the lipid micelles during digestion, and increasing amounts of the antioxidant in that variety are more likely to be transported to the blood along with the fats.

Taking all this into consideration, the researchers processed red tomatoes into deuce kinds of sauce: a sauce rich in cis-lycopene, the bent configuration, and a sauce containing mostly all-trans-lycopene, the linear form. Both sauces were flavored similarly and initially heated using the same methods. Corn oil was added to both sauces as well. But the sauce designed to produce lycopene in the bent molecular forms was subjected to a second base round of heating at 260 degrees Fahrenheit for 40 minutes. The resulting sauce contained nine times more cis-isomers than the regularly processed sauce.

Twelve people participated in a study of the sauces, and all ate both kinds of sauce over the course of the study. After each meal, researchers took samples of participants' blood seven times during the following 9 1/2 hours to measure lycopene levels. The scientists ill-used a special testing method to dissect lycopene levels in the blood associated only with the tomato sauce repast, avoiding whatever other possible sources of those compounds in the bloodstream.

Research participants had a 55 per centum increase in total lycopene absorption after eating the specially processed sauce when compared to their lycopene blood levels after eating the regular sauce. This finding reinforced the anticipation that the bent forms of lycopene are more easily absorbed into human blood, Schwartz said.

Details of this field of study were first gear published in the British Journal of Nutrition in 2007. Additional clinical trials are ongoing.

Schwartz said most currently available commercial products don't check the bent forms of lycopene molecules. But he noted that some home cooking practices might be able to produce the same results as the special processing method he and colleagues designed.

"Some people like to cook tomato sauce for prolonged periods, sometimes reheating it day after mean solar day, because it tastes better on the second and third day. They bring fat by using oil or meat, and that's going to start to induce cis-isomers of lycopene if productive is present and the cooking continues," Schwartz said. "So it's possible people could induct this process and increment lycopene absorption by procedure food preparation procedures, as well."

Much of this research is supported by the Ohio Agricultural Research and Development Center Competitive Grants Program, the National Center of Research Resources of the National Institutes of Health, the National Cancer Institute, and the U.S. Department of Agriculture Initiative for Future Agricultural & Food Systems.

Source: Steven Schwartz

Ohio State University

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Thursday 14 August 2008

MTV Elects LANE FOUR to Rock Shoreline Before Linkin Park and Chris Cornell on the Projekt Revolution Tour

SAN FRANCISCO, Aug. 7 -- MTV's "Rock the Revolution"
winners LANE FOUR will be one of three bands that won the opportunity to
rock the stage at Shoreline Amphitheater this Saturday. The summer's
premier stone tour, Projekt Revolution, comes to San Francisco featuring
Linkin Park, Chris Cornell, The Bravery, Atreyu, Hawthorne Heights, and a
host of other headline-worthy acts including LANE FOUR.

LANE FOUR is fronted by 2 remarkable young alternative hard rock
artists: lead isaac M. Singer, LAYLA BROOKLYN ALLMAN, is the 15-year old girl of
Rock n Roll Hall of Famer, GREGG ALLMAN, of the legendary Allman Brothers
Band. The fire that burns in the family genes is alive and kicking in this
improbable, attractive blonde powerhouse! Equally as vibrant and singular is
15-year old NICK LOIACONO whose dynamic, scorching and technically creative
guitar work is a howling compliment to this unmistakably professional thomas Young
band.

"When we started this tour, our approximation [was] to showcase groups that were
doing something revolutionary, something original, something different,"
says Mike Shinoda of Linkin Park. Shinoda says the tour isn't just for
Linkin Park fans, and he loves how fans of other bands can derive to it,
check out the other acts and find out about unexampled music. He adds, "we hope
that some day, fans toilet look support and say, 'Oh, I remember the first clock time I
saw skunk; this is a ring that I knew was going to be doing something
in truth great and different in the future.'"

LANE FOUR is that kind of dance orchestra. It is four 15-year olds with a love
for new alternative hard rock music, each with a different musical taste
and a unique elbow room to blend them, creating a profound that is their have. LAYLA
ALLMAN fronts the dance band with the hard driving vocals one would expect from a
much older singer. "I am very excited to be performing during the Projekt
Revolution Tour and to get photo with new fans, it is so cool that MTV
and Verizon came up with this idea for new bands and fans to connect," said
LAYLA ALLMAN, daughter of Southern Rocker Legend GREGG ALLMAN. "I remember
being 15, and what my first band sounded like, I bid we were as pixilated as
LANE FOUR," stated GREGG ALLMAN.

Here in San Francisco, MTV2 encouraged over 150 bands participation in
the contest that allowed the help of family, friends and fans to vote
on-line to be considered for the opening slot. MTV then chose three bands
among the 12 top vote getters to perform at the concert, including LANE
FOUR. Their live shows are senior high school energy that compliments their sound and
their youth.

LANE FOUR Band Members include:
-- Layla Allman -- Vocals, Keys,
-- Austin Dunn -- Bass Guitar
-- Nick Loiacono -- Lead Guitar
-- Eric Perkins -- Drums

Linkin Park's brainchild, Projekt Revolution defiantly embraces the
tenets originally espoused by Lollapalooza -- melodic revolution, artistic
camaraderie and genre diversity. "To portion Shoreline with a band that has
sold o'er 40 one thousand thousand albums general and has earned deuce GRAMMY(R) Awards
is a majuscule experience at 15 long time old," says Nick Loiacono, Lead Guitarist
for LANE FOUR. He adds, "their approach to a touring festival that is not
one-sided -- it's a alloy tour, alternative tour and a rap tour all
mixed together and we are a little part of the flavor of what today's youth
can bring to the stage...'New Alternative Hard Rock.'"

The Shoreline Amphitheater provides a unique open air atmosphere and a
full day of enjoyment for fans of all genres. LANE FOUR rocks the stage at
1:00 PM on the Revolution Stage. There will be two stages of amusement,
meet and greets, creative person signings, hearing stations and more.

The Projekt Revolution Tour is sponsored by Verizon Wireless -- Verizon
Wireless is a joint venture of Verizon Communications and Vodafone.

About MTV2 "Rock the Revolution"

MTV2 Bay Area and Comcast challenged local artists to compete for the
once in a life-time shot to open Linkin Park's Projekt Revolution. 159
artists entered and afterwards more than 890,000 votes, the fans declared their
top 12 picks. MTV2's euphony panel reviewed each finalist and afterwards much
deliberation, they induce selected the 3 bands to represent the Bay Area on
the Revolution stage at the Shoreline Amphitheatre on August 9th.

About LANE FOUR

For more information on LANE FOUR visit
http://www.myspace.com/lanefour.

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